I suppose that depends on why Itachi wiped out the other Uchiha. If he did it because of some flaw he perceived in them then it might be possible that Orochimaru was behind that flaw. Since I have no idea what sort of background you have for Orochimaru other than apparently working at Hyuuga Corp at some point I can't really help much.

Though it's obvious that Hyuuga Corp has some biomedical stuff going on, maybe they developed the Uchiha? Possibly Orochimaru was working on a way to become "immortal" by downloading a person's lifetime experience and knowledge into a blank Uchiha and Itachi discovered that fact?

Maybe Itachi is a failed attempt at that download process and that's why he went nuts. If someone decided they liked the way Itachi developed they might have copied his specs for Sasuke which would give Itachi a reason not to destroy him and a way for Orochimaru not to know about him (and to become interested in him later if you want to go that way).